Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | AKT1 | P31749 | 6/20 | 0.44 |
| ▸ | AKT2 | P31751 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361914 | 0.82 | KDM4E (0.46) | ALDH1A1AKT1AKT2KDM4EHPGD | |
| SCHEMBL362526 | 0.78 | KMT2A (0.40) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL8012335 | 0.78 | MAP4K4 (0.55) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL2967067 | 0.77 | AKT1 (0.45) | ALDH1A1AKT1AKT2KDM4EHPGD | |
| SCHEMBL2968149 | 0.77 | HPGD (0.41) | ALDH1A1AKT1AKT2KDM4EHPGD | |
| SCHEMBL3702122 | 0.76 | AKT1 (0.54) | ALDH1A1AKT1AKT2KDM4EHPGD | |
| SCHEMBL3702899 | 0.75 | AKT1 (0.47) | ALDH1A1AKT1AKT2KDM4EHPGD | |
| SCHEMBL867493 | 0.71 | AKT1 (0.56) | AKT1AKT2 | |
| SCHEMBL867191 | 0.70 | SRC (0.39) | ALDH1A1KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL3707392 | 0.69 | AKT1 (0.45) | ALDH1A1AKT1AKT2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |