Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896614 | 0.84 | AKT1 (0.60) | AKT1AKT2 | |
| SCHEMBL3712735 | 0.79 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL23877936 | 0.79 | NTRK1 (0.61) | AKT1AKT2 | |
| SCHEMBL2893422 | 0.79 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL2893433 | 0.79 | AKT1 (0.51) | AKT1AKT2 | |
| SCHEMBL1353014 | 0.76 | AKT1 (0.61) | AKT1AKT2 | |
| SCHEMBL2896545 | 0.76 | AKT1 (0.78) | AKT1AKT2 | |
| SCHEMBL3897323 | 0.75 | AKT1 (0.79) | AKT1AKT2 | |
| SCHEMBL3903351 | 0.74 | AKT1 (0.65) | AKT1AKT2 | |
| SCHEMBL13233232 | 0.74 | AKT1 (1.00) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |