Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.46 |
| ▸ | HRH1 | P35367 | 6/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788619 | 0.91 | HRH4 (0.45) | TLR7MAPTHRH4HRH1HRH3 | |
| SCHEMBL3713005 | 0.90 | PDE10A (0.48) | TLR7MAPTPDE4APDE4BPDE4C | |
| SCHEMBL13285966 | 0.87 | TSHR (0.46) | TLR7MAPT | |
| SCHEMBL3704626 | 0.85 | HRH4 (0.52) | TLR7HRH4HRH1HRH2HRH3 | |
| SCHEMBL3785017 | 0.82 | TLR9 (0.49) | TLR7MAPTHRH4LMNA | |
| SCHEMBL3786031 | 0.82 | CNR2 (0.42) | TLR7MAPTHRH4HRH1LMNA | |
| SCHEMBL13286132 | 0.81 | TLR9 (0.49) | TLR7MAPTLMNA | |
| SCHEMBL3702927 | 0.81 | TLR7 (0.45) | TLR7MAPTPDE4APDE4BPDE4C | |
| SCHEMBL3791449 | 0.81 | PDE10A (0.49) | MAPTLMNA | |
| SCHEMBL3785493 | 0.81 | TLR7 (0.43) | TLR7MAPTHRH4HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |