Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744296 | 1.00 | AKT1 (0.45) | AKT1CDK2FFAR1SYKSGK1 | |
| SCHEMBL2549646 | 0.89 | AKT1 (0.42) | AKT1CDK2FFAR1SYKSGK1 | |
| SCHEMBL2545072 | 0.84 | AKT1 (0.38) | AKT1CDK2FFAR1SYKFFAR2 | |
| SCHEMBL2545074 | 0.84 | AKT1 (0.38) | AKT1CDK2FFAR1SYKFFAR2 | |
| SCHEMBL12266153 | 0.83 | AKT1 (0.57) | AKT1CDK2SGK1 | |
| SCHEMBL1742573 | 0.83 | AKT1 (0.57) | AKT1CDK2SGK1 | |
| SCHEMBL1744260 | 0.82 | AKT1 (0.43) | AKT1CDK2FFAR1SGK1PPARD | |
| SCHEMBL1744259 | 0.82 | AKT1 (0.43) | AKT1CDK2FFAR1SYKSGK1 | |
| SCHEMBL2544590 | 0.82 | AKT1 (0.43) | AKT1CDK2FFAR1SYKSGK1 | |
| SCHEMBL12241774 | 0.82 | PTPRB (0.38) | AKT1CDK2SYKGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |