Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.62 |
| ▸ | PI4KA | P42356 | 13/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.62 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.59 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1127383 | 0.99 | SCN4A (0.61) | SCN4AEPHX2PIK3CDPIK3CAPI4KA | |
| SCHEMBL17969171 | 0.84 | SCN4A (0.77) | SCN4AEPHX2PIK3CDPIK3CAPI4KA | |
| SCHEMBL31114667 | 0.83 | SCN4A (0.70) | SCN4AEPHX2PIK3CDPIK3CAPI4KA | |
| SCHEMBL25256553 | 0.83 | SCN4A (0.70) | SCN4AEPHX2PIK3CDPIK3CAPI4KA | |
| SCHEMBL25303323 | 0.79 | PI4KA (0.72) | PIK3CDPIK3CAPI4KAPI4KBPIK3CG | |
| SCHEMBL12543471 | 0.79 | PI4KA (0.66) | PIK3CDPIK3CAPI4KAPI4KBPIK3CG | |
| SCHEMBL29646253 | 0.79 | PIK3CA (0.82) | PIK3CDPIK3CAPI4KAPI4KBPIK3CG | |
| SCHEMBL5532470 | 0.79 | PIK3CA (0.82) | PIK3CDPIK3CAPI4KAPI4KBPIK3CG | |
| SCHEMBL1417399 | 0.78 | SCN4A (1.00) | SCN4AEPHX2PIK3CDPIK3CAPI4KA | |
| SCHEMBL10084977 | 0.78 | PIK3CD (0.55) | PIK3CDPIK3CAPI4KAPI4KBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110135603-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-09 | — | — | US | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009129211-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110135603-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | PIK3CA, PIK3CG, PIK3CD | SCN4A 3394/4885EPHX2 3144/4885PIK3CD 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.