Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | VDR | P11473 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702564 | 0.93 | LPAR1 (0.59) | LPAR1LPAR3LPAR2ALOX5ALOX5AP | |
| SCHEMBL2336641 | 0.93 | LPAR1 (0.57) | LPAR1LPAR3LPAR2ALDH1A1SCN9A | |
| SCHEMBL3714447 | 0.87 | LPAR1 (0.51) | LPAR1LPAR3LPAR2NPC1ALDH1A1 | |
| SCHEMBL2339547 | 0.87 | LPAR1 (0.56) | LPAR1LPAR3LPAR2ALDH1A1SCN9A | |
| SCHEMBL3717699 | 0.86 | LPAR1 (0.45) | LPAR1LPAR3LPAR2SCN9ASCN5A | |
| SCHEMBL3700512 | 0.85 | LPAR1 (0.48) | LPAR1LPAR3LPAR2SCN9ASCN5A | |
| SCHEMBL3710887 | 0.85 | NR1H4 (0.48) | LPAR1LPAR3LPAR2NPC1RAB9A | |
| SCHEMBL3700613 | 0.85 | LPAR1 (0.61) | LPAR1LPAR3LPAR2RAB9AALOX5 | |
| SCHEMBL3707585 | 0.85 | LPAR1 (0.53) | LPAR1LPAR3LPAR2ALDH1A1SCN9A | |
| SCHEMBL3704466 | 0.85 | LPAR1 (0.47) | LPAR1LPAR3LPAR2SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |