Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.72 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704552 | 0.84 | PDE10A (0.73) | PDE10ATNFGSK3BCYP2D6SMN1; SMN2 | |
| SCHEMBL1636932 | 0.84 | PDE10A (1.00) | PDE10AHTR1AADRA1DHTR7ADRA1A | |
| SCHEMBL3658478 | 0.81 | PDE10A (0.67) | PDE10A | |
| SCHEMBL3715617 | 0.80 | PDE10A (0.57) | PDE10AGSK3B | |
| SCHEMBL4718645 | 0.74 | PDE10A (0.63) | PDE10AGSK3BCYP2D6 | |
| SCHEMBL1639261 | 0.74 | PDE10A (0.85) | PDE10A | |
| SCHEMBL1638492 | 0.74 | PDE10A (1.00) | PDE10AACHEBACE1 | |
| SCHEMBL1638956 | 0.74 | PDE10A (0.83) | PDE10AHTR1AADRA1DHTR7ADRA1A | |
| SCHEMBL1638127 | 0.73 | PDE10A (1.00) | PDE10AACHEBACE1 | |
| SCHEMBL1638948 | 0.73 | PDE10A (0.83) | PDE10AACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203438-A1 | CYANOISOQUINOLINE | H. Lundbeck A/S (DK) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009036766-A1 | CYANOISOQUINOLINE | H. LUNDBECK A/S (DK) | 2009-03-26 | — | — | WO | disclosed |