SCHEMBL3708946

SCHEMBL3708946

COc1ccc(F)c(-c2ccc(COc3ccc(F)c(CCCCC(=O)O)c3)cc2C2=CCCC2(C)C)c1

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 19/20 0.76
FFAR4 Q5NUL3 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3710816 0.89 FFAR1 (0.74) FFAR1FFAR4
SCHEMBL3717274 0.89 FFAR1 (0.71) FFAR1
SCHEMBL2497548 0.86 FFAR1 (1.00) FFAR1
SCHEMBL2495364 0.82 FFAR1 (0.78) FFAR1FFAR4
SCHEMBL13424461 0.81 FFAR1 (0.74) FFAR1
SCHEMBL2502995 0.80 FFAR1 (0.79) FFAR1
SCHEMBL3712712 0.80 FFAR1 (0.78) FFAR1
SCHEMBL2495660 0.80 FFAR1 (0.78) FFAR1
SCHEMBL2499270 0.80 FFAR1 (0.78) FFAR1
SCHEMBL2495886 0.80 FFAR1 (0.79) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205548-A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS Amgen, Inc (US) 2010-07-14 EP disclosed
WO-2009048527-A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS AMGEN INC. (US) 2009-04-16 WO disclosed