Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701531 | 0.82 | MEN1 (0.46) | LMNARECQLCYP2D6KDM4E | |
| SCHEMBL15538380 | 0.80 | KDM4E (0.61) | TDO2IDO2IDO1LMNAMPO | |
| SCHEMBL19576287 | 0.79 | PIK3CD (0.57) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL3705568 | 0.78 | KDM4E (0.63) | LMNARECQLPOLBPTGS2KDM4E | |
| SCHEMBL20067790 | 0.77 | PIK3CD (0.50) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL12885786 | 0.74 | PIK3CD (0.55) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL15815739 | 0.74 | PIK3CD (0.57) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL15815737 | 0.74 | PIK3CD (0.57) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL15813106 | 0.74 | PIK3CD (0.55) | TDO2IDO2IDO1PIK3CDPIK3R1 | |
| SCHEMBL20067856 | 0.73 | PIK3CD (0.61) | TDO2IDO2PIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609674-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067824-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122890-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122890-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNQ3 | TDO2 4481/4885IDO2 4395/4885IDO1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.