Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709343 | 0.90 | NEK1 (0.52) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL454311 | 0.90 | NEK1 (0.53) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL3707429 | 0.89 | AXL (0.61) | DYRK1ANTRK1AAK1CDK2AXL | |
| SCHEMBL3506503 | 0.88 | DYRK1A (0.53) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL28770490 | 0.87 | NEK1 (0.58) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL858474 | 0.85 | PAK1 (0.58) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL299545 | 0.84 | CYP2C9 (0.48) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL413484 | 0.83 | NEK1 (0.55) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL3506502 | 0.82 | DYRK1A (0.51) | DYRK1ANTRK1PIK3CANEK1BRD4 | |
| SCHEMBL3699186 | 0.81 | NTRK1 (0.64) | DYRK1ANTRK1PIK3CANEK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | DYRK1A 673/4885NTRK1 1554/4885PIK3CA 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.