Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.63 |
| ▸ | GRM8 | O00222 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502005 | 0.92 | GRM4 (0.74) | GRM4GRM8NPC1PKMRAB9A | |
| SCHEMBL370475 | 0.88 | GRM4 (0.79) | GRM4GRM8NPC1PKMRAB9A | |
| SCHEMBL371229 | 0.85 | GRM4 (0.53) | GRM4GRM8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL368850 | 0.82 | GRM4 (0.56) | GRM4GRM8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15166654 | 0.80 | GRM4 (0.61) | GRM4GRM8KCNH2MAPK8AURKB | |
| SCHEMBL369060 | 0.78 | GRM4 (1.00) | GRM4GRM8NPC1PKMRAB9A | |
| SCHEMBL12482272 | 0.77 | GRM4 (0.53) | GRM4GRM8MAPK8AURKASYK | |
| SCHEMBL370007 | 0.75 | GRM4 (0.70) | GRM4GRM8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL370559 | 0.74 | GRM4 (0.74) | GRM4GRM8NPC1PKMRAB9A | |
| SCHEMBL370278 | 0.73 | GRM4 (0.77) | GRM4GRM8NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |