Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.59 |
| ▸ | AKT2 | P31751 | 12/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800463 | 0.90 | AKT1 (0.60) | AKT1AKT2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL13256520 | 0.83 | AKT1 (0.47) | AKT1AKT2KDM4EALDH1A1HPGD | |
| SCHEMBL3702794 | 0.79 | AKT1 (0.56) | AKT1AKT2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL2978431 | 0.78 | AKT1 (0.49) | AKT1AKT2KDM4EALDH1A1HPGD | |
| SCHEMBL13256563 | 0.78 | AKT1 (0.42) | AKT1AKT2MAPT | |
| SCHEMBL13256228 | 0.74 | AKT1 (0.78) | AKT1AKT2 | |
| SCHEMBL13256519 | 0.73 | AKT1 (0.49) | AKT1AKT2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL362285 | 0.73 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL15106691 | 0.72 | AKT1 (0.54) | AKT1AKT2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL13256521 | 0.72 | AKT1 (0.40) | AKT1AKT2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-B1 | FUSED PYRIMIDINES | BAYER IP GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-8957064-B2 | Fused pyrimidines | BAYER INTELLECTUAL PROPERTY GMBH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957064-B2 | Fused pyrimidines | BAYER INTELLECTUAL PROPERTY GMBH (US) | 2015-02-17 | — | — | US | disclosed |
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |