Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.70 |
| ▸ | JAK1 | P23458 | 13/20 | 0.68 |
| ▸ | JAK3 | P52333 | 13/20 | 0.68 |
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | ITK | Q08881 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL341638 | 0.95 | SYK (0.63) | SYKJAK1JAK3JAK2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL29610528 | 0.95 | SYK (0.63) | SYKJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL17060835 | 0.92 | JAK1 (0.64) | SYKJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL3702834 | 0.90 | JAK1 (0.71) | SYKJAK1JAK3JAK2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL340136 | 0.87 | JAK1 (0.58) | SYKJAK1JAK3JAK2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL341373 | 0.86 | JAK1 (0.65) | SYKJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL10176787 | 0.84 | JAK1 (0.74) | SYKJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL656652 | 0.83 | SYK (1.00) | SYKJAK3JAK2EGFRITK | |
| SCHEMBL524874 | 0.82 | JAK1 (0.66) | SYKJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL15389492 | 0.82 | JAK1 (0.70) | SYKJAK1JAK3JAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | claimed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | disclosed |