SCHEMBL3710123

SCHEMBL3710123

COCC12CCC(COC)(CC(c3ccc(C(N)=O)c(C4=CCC(C)(C)CC4)c3)C1)O2

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 9/20 0.35
TBK1 Q9UHD2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18297742 0.90 CSF1R (0.34) CSF1R
SCHEMBL3649387 0.90 CSF1R (0.36) CSF1RTBK1
SCHEMBL3700910 0.87 CSF1R (0.33) CSF1R
SCHEMBL3653207 0.87 CSF1R (0.33) CSF1R
SCHEMBL3711700 0.87 CSF1R (0.33) CSF1R
SCHEMBL23808522 0.84 CSF1R (0.32) CSF1R
SCHEMBL3702132 0.83 CSF1R (0.38) CSF1R
SCHEMBL3706717 0.83 CSF1R (0.38) CSF1R
SCHEMBL18297750 0.82 CSF1R (0.38) CSF1RTBK1
SCHEMBL19264353 0.81 CSF1R (0.31) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2215079-A1 INHIBITORS OF C-FMS KINASE Janssen Pharmaceutica N.V. (BE) 2010-08-11 EP disclosed
WO-2009052237-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2009-04-23 WO disclosed