Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 8/20 | 0.57 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743779 | 0.90 | MARK3 (0.55) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL1691900 | 0.84 | MARK3 (0.58) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL10066136 | 0.83 | MARK3 (0.68) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL1692068 | 0.82 | MARK3 (0.81) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL10066126 | 0.82 | MARK3 (0.81) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL1691499 | 0.82 | MARK3 (0.81) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL10066133 | 0.82 | MARK3 (0.81) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL15187428 | 0.82 | IRAK4 (0.56) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL15187447 | 0.82 | MARK3 (0.49) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL1743475 | 0.82 | MARK3 (0.41) | MARK3SGK1CHEK1IKBKBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083145-A1 | IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-07-22 | — | — | WO | disclosed |