Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298562 | 0.85 | MAP2K1 (0.51) | CAMKK2MAP2K1NEK2BRAFKDR | |
| SCHEMBL857560 | 0.84 | MAP2K1 (0.52) | CAMKK2MAP2K1NEK2BRAFKDR | |
| SCHEMBL3709076 | 0.83 | NEK2 (0.63) | CAMKK2MAP2K1NEK2KDRCNR2 | |
| SCHEMBL3697175 | 0.82 | BRAF (0.49) | MAP2K1NEK2BRAFKDRRIPK1 | |
| SCHEMBL12148130 | 0.82 | MAP2K1 (0.50) | CAMKK2MAP2K1NEK2BRAFKDR | |
| SCHEMBL3505473 | 0.81 | BRAF (0.52) | MAP2K1NEK2BRAFKDRRIPK1 | |
| SCHEMBL3707415 | 0.81 | BRAF (0.52) | MAP2K1NEK2BRAFKDRRIPK1 | |
| SCHEMBL857351 | 0.81 | MAP2K1 (0.57) | CAMKK2MAP2K1NEK2BRAFKDR | |
| SCHEMBL27708260 | 0.80 | MAP2K1 (0.71) | CAMKK2MAP2K1NEK2BRAFKDR | |
| SCHEMBL857086 | 0.80 | MAP2K1 (0.57) | MAP2K1NEK2BRAFKDRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | CAMKK2 497/4885MAP2K1 131/4885NEK2 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.