Purine

Purine

SCHEMBL37119

[NaH].c1ncc2nc[nH]c2n1

nearest known ligand 0.37

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4A O75164 1/20 0.37
KDM4B O94953 1/20 0.37
KDM5C P41229 1/20 0.37
KDM4C Q9H3R0 1/20 0.37
KDM5B Q9UGL1 1/20 0.37
KDM3A Q9Y4C1 1/20 0.37
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
HPGD P15428 2/20 0.35
TP53 P04637 1/20 0.35
PTGS1 P23219 1/20 0.35
HBB P68871 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPT P10636 2/20 0.34
APEX1 P27695 1/20 0.34
RECQL P46063 1/20 0.34
BLM P54132 1/20 0.34
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Purine SCHEMBL3157 0.98
Purine SCHEMBL29456595 0.98
Purine SCHEMBL2120547 0.98 KDM4A (0.38) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL5578775 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL5611476 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL9603027 0.95
Purine SCHEMBL311318 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL6438162 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL7787135 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B
Purine SCHEMBL9057416 0.95 KDM4A (0.37) KDM4AKDM4BKDM5CKDM4CKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109294976-A A kind of serum free medium for supporting HEK293 cell suspension cultures 王晓柯 2019-02-01 CN claimed
CN-107236708-A A kind of serum free medium for supporting HeLa cell attachment cultures 王晓柯 2017-10-10 CN claimed
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP claimed
WO-2020192302-A1 PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF 广州必贝特医药技术有限公司 2020-10-01 WO disclosed
CN-109294976-A A kind of serum free medium for supporting HEK293 cell suspension cultures 王晓柯 2019-02-01 CN disclosed
CN-105125522-B A kind of hyaluronic acid-cationic drug ion pair particle 四川大学 2018-08-21 CN disclosed
CN-108348894-A Ozonolysis for compound activation and ozonolysis 空气交叉股份有限公司 2018-07-31 CN disclosed
CN-107430124-A The immunological detection and kit of mycoplasma pneumoniae 滋吾堂有限公司 2017-12-01 CN disclosed
CN-107407679-A The immunological detection and kit of mycoplasma pneumoniae 滋吾堂有限公司 2017-11-28 CN disclosed
CN-107236708-A A kind of serum free medium for supporting HeLa cell attachment cultures 王晓柯 2017-10-10 CN disclosed
EP-2467391-B1 PROCESS FOR THE PREPARATION OF CLADRIBINE SCINOPHARM KUNSHAN BIOCHEMICAL TECHNOLOGY CO LTD (CN) 2016-04-27 EP disclosed
US-20020052491-A1 Method for the production of 2-chloro-2' -deoxyadenosine (cladribine) and its 3,5-di-O-p-toluoyl derivative GERSZBERG SZEPSEL (AR) 2002-05-02 US disclosed
WO-2000064918-A1 METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE STERRENBELD BIOTECHNOLOGIE NORTH AMERICA, INC. (US) 2000-11-02 WO disclosed
CN-1040114-C Stereoselective glycosylation process LILLY CO ELI (US) 1998-10-07 CN disclosed
US-5532225-A TREATMENT OF HERPES VIRUS SRI INTERNATIONAL (US) 1996-07-02 US disclosed
CN-1085560-A Stereoselective glycosylation process LILLY CO ELI (US) 1994-04-20 CN disclosed
WO-1994003466-A1 ACYCLIC PURINE PHOSPHONATE NUCLEOTIDE ANALOGS AS ANTIVIRAL AGENTS, AND RELATED SYNTHETIC METHODS SRI INTERNATIONAL (US) 1994-02-17 WO disclosed
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052491-A1 Method for the production of 2-chloro-2' -deoxyadenosine (cladribine) and its 3,5-di-O-p-toluoyl derivative MTAP, TPMT, DCTD KDM4A 505/4885KDM4B 564/4885KDM5C 204/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.