Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714897 | 0.84 | HDAC1 (0.52) | HDAC6HDAC1FFAR1KDM1ASMPD1 | |
| SCHEMBL3713444 | 0.81 | HDAC6 (0.44) | HDAC6HDAC1FFAR1KDM1ASMPD1 | |
| SCHEMBL13188328 | 0.80 | HDAC6 (0.51) | HDAC6HDAC1FFAR1KDM1AHIF1A | |
| SCHEMBL400670 | 0.80 | HDAC1 (0.60) | HDAC6HDAC1FFAR1KDM1AHIF1A | |
| SCHEMBL13188263 | 0.79 | HDAC6 (0.42) | HDAC6HDAC1FFAR1KDM1AHIF1A | |
| SCHEMBL3713649 | 0.79 | HDAC1 (0.52) | HDAC6HDAC1FFAR1KDM1ASMPD1 | |
| SCHEMBL13188441 | 0.78 | CSF1R (0.43) | HDAC6HDAC1FFAR1KDM1ASMPD1 | |
| SCHEMBL3714241 | 0.78 | HDAC6 (0.41) | HDAC6HDAC1FFAR1KDM1AHIF1A | |
| SCHEMBL3721790 | 0.78 | HDAC6 (0.41) | HDAC6HDAC1FFAR1KDM1AHIF1A | |
| SCHEMBL3803200 | 0.78 | ALDH2 (0.42) | HDAC6HDAC1FFAR1KDM1AHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |