Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262424 | 0.94 | MEN1 (0.59) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL264235 | 0.90 | MEN1 (0.58) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL264484 | 0.90 | MEN1 (0.60) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL264988 | 0.86 | MEN1 (0.65) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL296147 | 0.83 | MAPT (0.48) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL264161 | 0.82 | CYP3A4 (0.55) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL263204 | 0.82 | MEN1 (0.65) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL264143 | 0.82 | MAPT (0.56) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL263909 | 0.82 | KMT2A (0.61) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL263689 | 0.81 | MAPT (0.55) | MEN1KMT2AMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133998-B2 | Bicyclic pyrimidine derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2012-03-13 | — | — | US | disclosed |