Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.59 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369428 | 0.85 | GRM4 (0.62) | GRM4GRM8PIK3CAKCNH2CHEK1 | |
| SCHEMBL367293 | 0.82 | GRM4 (0.63) | GRM4GRM8KCNH2ADORA3ADORA2A | |
| SCHEMBL369335 | 0.82 | GRM4 (0.40) | GRM4KCNH2TRPV4 | |
| SCHEMBL370857 | 0.77 | GRM4 (0.66) | GRM4GRM8KCNH2CHEK1ADORA3 | |
| SCHEMBL369152 | 0.77 | GRM4 (1.00) | GRM4GRM8KCNH2TRPV4KDR | |
| SCHEMBL369153 | 0.77 | GRM4 (0.65) | GRM4GRM8KCNH2CHEK1ADORA3 | |
| SCHEMBL3356535 | 0.76 | GRM4 (0.68) | GRM4GRM8KCNH2ADORA3ADORA2A | |
| SCHEMBL15166602 | 0.71 | GRM4 (0.59) | GRM4GRM8KCNH2CHEK1ROCK2 | |
| SCHEMBL366105 | 0.71 | GRM4 (0.70) | GRM4GRM8KCNH2ADORA3ADORA2A | |
| SCHEMBL369379 | 0.70 | GRM4 (0.82) | GRM4GRM8KCNH2TRPV4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |