Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 17/20 | 0.43 |
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604136 | 0.90 | GPBAR1 (0.43) | GPBAR1NR1H4 | |
| SCHEMBL15383100 | 0.82 | GPBAR1 (0.52) | GPBAR1 | |
| SCHEMBL601952 | 0.80 | GPBAR1 (0.43) | GPBAR1NR1H4 | |
| SCHEMBL601931 | 0.78 | GPBAR1 (0.53) | GPBAR1NR1H4 | |
| SCHEMBL600927 | 0.77 | GPBAR1 (0.56) | GPBAR1 | |
| SCHEMBL602418 | 0.77 | GPBAR1 (0.52) | GPBAR1NR1H4 | |
| SCHEMBL601616 | 0.76 | GPBAR1 (0.46) | GPBAR1 | |
| SCHEMBL603581 | 0.76 | GPBAR1 (0.46) | GPBAR1 | |
| SCHEMBL601478 | 0.76 | GPBAR1 (0.51) | GPBAR1 | |
| SCHEMBL605231 | 0.76 | GPBAR1 (0.51) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396304-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | Exelixis, Inc. (US) | 2011-12-21 | — | — | EP | claimed |
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | claimed |