Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 12/20 | 0.51 |
| ▸ | CDK2 | P24941 | 12/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.51 |
| ▸ | CDK9 | P50750 | 5/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 5/20 | 0.45 |
| ▸ | CCNT2 | O60583 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1354863 | 0.92 | CCNE1 (0.56) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1352736 | 0.89 | CCNE1 (0.47) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1355210 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1355393 | 0.88 | CDK2 (0.51) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1354660 | 0.87 | CCNE1 (0.57) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1355229 | 0.86 | CDK2 (0.49) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1354680 | 0.85 | CDK2 (0.53) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1354202 | 0.83 | CDK1 (0.56) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1355081 | 0.83 | CDK2 (0.54) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL1353769 | 0.82 | CDK2 (0.75) | CCNE1CDK2CCNT1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391626-A2 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010085924-A2 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2010-08-05 | — | — | WO | disclosed |