Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GALR1 | P47211 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472650 | 0.92 | TP53 (0.61) | TP53POLBHPGDALDH1A1LMNA | |
| SCHEMBL20068150 | 0.83 | TP53 (0.62) | TP53POLBHPGDALDH1A1LMNA | |
| SCHEMBL14714526 | 0.83 | CA1 (0.53) | TP53POLBHPGDALDH1A1LMNA | |
| SCHEMBL4193217 | 0.81 | TP53 (0.61) | TP53POLBHPGDGALR1 | |
| SCHEMBL8463066 | 0.81 | PLAU (0.51) | TP53POLBHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29617015 | 0.80 | TP53 (0.62) | TP53POLBHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5943767 | 0.79 | TRIM24 (0.61) | TP53POLBHPGDLMNASMN1; SMN2 | |
| SCHEMBL5863231 | 0.79 | TP53 (0.56) | TP53POLBHPGDALDH1A1LMNA | |
| SCHEMBL1537537 | 0.78 | NPC1 (0.60) | TP53POLBHPGDALDH1A1LMNA | |
| SCHEMBL2404818 | 0.78 | NPC1 (0.59) | TP53POLBHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |