Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.52 |
| ▸ | STAT6 | P42226 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913990 | 0.87 | SYK (0.66) | SYKJAK2JAK1JAK3 | |
| SCHEMBL913485 | 0.87 | SYK (0.69) | SYKJAK2JAK1JAK3EGFR | |
| SCHEMBL912950 | 0.86 | SYK (0.55) | SYKSTAT6JAK2JAK1JAK3 | |
| SCHEMBL913819 | 0.85 | JAK3 (0.61) | SYKJAK2JAK1JAK3EGFR | |
| SCHEMBL915079 | 0.85 | JAK2 (0.61) | SYKJAK2JAK1JAK3EGFR | |
| SCHEMBL913556 | 0.85 | SYK (0.54) | SYKJAK2JAK1JAK3 | |
| SCHEMBL14982156 | 0.84 | SYK (0.55) | SYKSTAT6JAK2JAK1JAK3 | |
| SCHEMBL913762 | 0.84 | SYK (0.60) | SYKJAK2JAK1JAK3EGFR | |
| SCHEMBL913830 | 0.82 | SYK (0.58) | SYKJAK2JAK1JAK3 | |
| SCHEMBL913953 | 0.80 | SYK (0.65) | SYKJAK2JAK1JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |