Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.43 |
| ▸ | HTR1A | P08908 | 15/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745346 | 0.83 | SLC6A4 (0.54) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL3719567 | 0.81 | SLC6A4 (0.31) | SLC6A4 | |
| SCHEMBL3726545 | 0.81 | SLC6A4 (0.35) | SLC6A4 | |
| SCHEMBL3711091 | 0.80 | SLC6A4 (0.36) | SLC6A4ALDH1A1CYP2D6L3MBTL1MAPT | |
| SCHEMBL3713287 | 0.77 | SLC6A4 (0.43) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL925035 | 0.75 | SLC6A4 (0.46) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL3713282 | 0.75 | SLC6A4 (0.43) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL3713284 | 0.74 | SLC6A4 (0.42) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL20745053 | 0.71 | SLC6A4 (0.53) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL20745095 | 0.70 | SLC6A4 (0.43) | SLC6A4HTR1AALDH1A1CYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231677-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074674-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |