Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.61 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.61 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | MITF | O75030 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1889952 | 0.99 | DNMT1 (0.60) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL3709576 | 0.89 | KMT2A (0.54) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL1886837 | 0.89 | DNMT1 (0.80) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL1887399 | 0.89 | DNMT1 (0.80) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL1880955 | 0.88 | KMT2A (0.53) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL12240516 | 0.85 | DNMT1 (0.70) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL1884506 | 0.84 | DNMT1 (0.68) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL1886368 | 0.84 | MAPT (0.70) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL1880964 | 0.79 | DNMT1 (0.65) | DNMT1DNMT3LDNMT3AMAPTPOLB | |
| SCHEMBL12672276 | 0.78 | DNMT1 (0.64) | DNMT1DNMT3LDNMT3AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205586-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SuperGen, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009049132-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-04-16 | — | — | WO | disclosed |