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Defoslimod

Defoslimod

SCHEMBL3714038

CCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@H]1[C@H](OC[C@H]2OC(OP(=O)(O)O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](O)[C@@H]2O)O[C@H](CO)[C@@H](OP(=O)(O)O)[C@@H]1O

nearest known ligand 0.75

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Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TLR4 O00206 18/20 0.75
▸ LY96 Q9Y6Y9 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Defoslimod SCHEMBL13752580 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL13231311 1.00 TLR4 (0.75) TLR4LY96
SCHEMBL8209575 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL12469694 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL132545 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL13705691 1.00 TLR4 (0.75) TLR4LY96
SCHEMBL8208245 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL13744280 1.00 TLR4 (0.75) TLR4LY96
Defoslimod SCHEMBL19839002 1.00 TLR4 (0.75) TLR4LY96
SCHEMBL8209574 1.00 TLR4 (0.75) TLR4LY96

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120972-A1 INACTIVATED DENGUE VIRUS VACCINE WITH ALUMINIUM-FREE ADJUVANT GLAXOSMITHKLINE BIOLOG SA (BE) 2016-05-05 — — US disclosed
US-9265821-B2 Inactivated dengue virus vaccine with aluminium-free adjuvant GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-02-23 — — US disclosed
EP-2398821-A1 INACTIVATED DENGUE VIRUS VACCINE WITH ALUMINIUM-FREE ADJUVANT GlaxoSmithKline Biologicals S.A. (BE) 2011-12-28 — — EP disclosed
WO-2010094663-A1 INACTIVATED DENGUE VIRUS VACCINE WITH ALUMINIUM-FREE ADJUVANT GLAXOSMITHKLINE BIOLOGICALS S.A. (BE) 2010-08-26 — — WO disclosed