⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714070 | 0.94 | GRM5 (0.31) | — | |
| SCHEMBL3769514 | 0.82 | GRM5 (0.36) | — | |
| SCHEMBL2837127 | 0.79 | GRM5 (0.39) | — | |
| SCHEMBL3724178 | 0.78 | GRM5 (0.37) | — | |
| SCHEMBL992103 | 0.71 | KMT2A (0.46) | — | |
| SCHEMBL991625 | 0.71 | GRM5 (0.49) | — | |
| SCHEMBL990983 | 0.70 | GRM5 (0.42) | — | |
| SCHEMBL990821 | 0.70 | GRM5 (0.44) | — | |
| SCHEMBL990965 | 0.70 | GRM5 (0.44) | — | |
| SCHEMBL3792920 | 0.68 | GRM5 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2211859-A2 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009047296-A2 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS FOR THE TREATMENT OP PARKINSON'S DISEASE | NOVARTIS AG (CH) | 2009-04-16 | — | — | WO | disclosed |