Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 11/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712344 | 0.91 | JAK3 (0.59) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL913574 | 0.91 | STAT6 (0.60) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL3715522 | 0.91 | JAK3 (0.55) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL3711925 | 0.90 | JAK3 (0.58) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3713183 | 0.87 | JAK3 (0.54) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3718768 | 0.85 | JAK3 (0.55) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3723332 | 0.85 | STAT6 (0.55) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3715842 | 0.84 | JAK3 (0.51) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL913837 | 0.83 | SYK (0.54) | JAK3JAK2JAK1MAPK8MAPK9 | |
| SCHEMBL3715960 | 0.83 | STAT6 (0.57) | JAK3JAK2JAK1STAT6MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |