Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27075730 | 0.89 | PLK1 (0.70) | AURKAAURKBSRCITKPLK1 | |
| SCHEMBL27075736 | 0.87 | AURKA (0.73) | AURKAAURKBSRCITKPLK1 | |
| SCHEMBL27075726 | 0.86 | NPC1 (0.67) | AURKAAURKBSRCITKPLK1 | |
| SCHEMBL27075735 | 0.85 | AURKA (0.66) | AURKAAURKBSRCSYK | |
| SCHEMBL27075738 | 0.84 | TNNI3K (0.62) | AURKAAURKBSRCITKPLK1 | |
| SCHEMBL27075737 | 0.83 | BRAF (0.60) | AURKAAURKBSRCITKPLK1 | |
| SCHEMBL12968974 | 0.83 | ROCK1 (0.66) | AURKAAURKBSRCITKRAB9A | |
| Hydrochloric Acid SCHEMBL12813262 | 0.82 | ROCK1 (0.64) | AURKAAURKBSRCITKRAB9A | |
| SCHEMBL18780746 | 0.81 | AURKA (0.54) | AURKAAURKBNPC1RAB9ASYK | |
| SCHEMBL27075734 | 0.80 | AURKA (0.56) | AURKAAURKBSRCITKPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |