Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | FABP7 | O15540 | 2/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714709 | 0.95 | KMT2A (0.46) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL21996844 | 0.87 | KMT2A (0.40) | KMT2AEPHX2CASP3TDP1 | |
| SCHEMBL31072215 | 0.87 | KMT2A (0.40) | KMT2AEPHX2CASP3TDP1 | |
| SCHEMBL10066114 | 0.87 | KMT2A (0.40) | KMT2AEPHX2CASP3TDP1 | |
| SCHEMBL10066113 | 0.85 | KMT2A (0.47) | KMT2AEPHX2CASP3FABP7FABP5 | |
| Hydrochloric Acid SCHEMBL1691807 | 0.84 | KMT2A (0.46) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL21996723 | 0.83 | KMT2A (0.47) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL1743475 | 0.81 | MARK3 (0.41) | KMT2AEPHX2CASP3TDP1 | |
| SCHEMBL762530 | 0.78 | KMT2A (0.50) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL20042065 | 0.78 | KMT2A (0.50) | KMT2AEPHX2CASP3FABP7FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083145-A1 | IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-07-22 | — | — | WO | disclosed |