Sugi Predict

Sugi Predict / Compounds / SCHEMBL3714942

SCHEMBL3714942

SCHEMBL3714942

c1cc2nc(Nc3ccc4c(c3)CCNC4)nc(NC3CC3)c2o1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 12/20 0.59
▸ TYRO3 Q06418 4/20 0.59
▸ DAPK3 O43293 2/20 0.59
▸ JAK2 O60674 2/20 0.59
▸ PAK4 O96013 2/20 0.59
▸ ABL1 P00519 2/20 0.59
▸ LCK P06239 2/20 0.59
▸ FYN P06241 2/20 0.59
▸ RET P07949 2/20 0.59
▸ LTK P29376 2/20 0.59
▸ GRK5 P34947 2/20 0.59
▸ MAPK8 P45983 2/20 0.59
▸ CSNK1A1 P48729 2/20 0.59
▸ TNK2 Q07912 2/20 0.59
▸ MAP4K2 Q12851 2/20 0.59
▸ ALK Q9UM73 2/20 0.59
▸ STK16 O75716 1/20 0.59
▸ MAP4K4 O95819 1/20 0.59
▸ TTK P33981 1/20 0.59
▸ KDR P35968 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3699874 0.85 SYK (0.52) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL1709824 0.80 SYK (0.57) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL7605998 0.80 SYK (0.58) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL3712906 0.79 SYK (0.59) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL3708538 0.78 SYK (0.71) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL1709798 0.78 SYK (0.77) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL3701359 0.78 SYK (0.56) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL3704603 0.78 SYK (0.53) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL3713456 0.77 SYK (0.73) SYKTYRO3DAPK3JAK2PAK4
SCHEMBL1709793 0.77 SYK (0.63) SYKTYRO3DAPK3JAK2PAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US claimed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US claimed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
WO-2012048222-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-04-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS CDK2, DPYD, CDK3 SYK 1176/4885TYRO3 1079/4885DAPK3 149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.