Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 19/20 | 0.66 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.66 |
| ▸ | MTOR | P42345 | 2/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725683 | 0.93 | PRKDC (0.67) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3717309 | 0.93 | PRKDC (0.67) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3719447 | 0.89 | PRKDC (0.62) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3714305 | 0.87 | PRKDC (0.60) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3811086 | 0.87 | PRKDC (0.63) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3721340 | 0.86 | PRKDC (0.72) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL13050354 | 0.86 | PRKDC (0.58) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3723857 | 0.85 | PRKDC (0.66) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL3715022 | 0.85 | PRKDC (0.77) | PRKDCBRDTPIK3CAPIK3CBMTOR | |
| SCHEMBL13049360 | 0.85 | PRKDC (0.56) | PRKDCBRDTPIK3CAPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |