Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.48 |
| ▸ | KDM1A | O60341 | 10/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713122 | 0.88 | KDM5B (0.45) | EGFRFFAR1PTGESAKR1C3 | |
| SCHEMBL13187971 | 0.82 | HDAC1 (0.61) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL13187738 | 0.82 | HDAC1 (0.55) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL13188523 | 0.79 | HDAC1 (0.55) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL3721374 | 0.78 | FFAR1 (0.48) | HDAC1KDM1AFFAR1 | |
| SCHEMBL3713063 | 0.78 | HDAC1 (0.66) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL3714564 | 0.78 | KDM4E (0.49) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL3714897 | 0.77 | HDAC1 (0.52) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL13187716 | 0.73 | HDAC1 (0.55) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL13187834 | 0.73 | HDAC6 (0.42) | HDAC1HDAC6HDAC2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |