Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20986826 | 0.94 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ACYP2C19JAK2 | |
| SCHEMBL23164394 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL2858459 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL4512387 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19JAK2 | |
| SCHEMBL12815027 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19JAK2 | |
| SCHEMBL2857739 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL18149461 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19USP30 | |
| SCHEMBL18159775 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19USP30 | |
| SCHEMBL18159771 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19USP30 | |
| SCHEMBL20986848 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ACYP2C19JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091721-A1 | 3 -SUBSTITUTED 1-ARYLSULFONYLPIPERIDINE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |