Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2834513 | 0.88 | EPHX2 (0.45) | CNR1GAALMNAEPHX2HCRTR1 | |
| SCHEMBL2840532 | 0.88 | EPHX2 (0.45) | CNR1GAALMNAEPHX2HCRTR1 | |
| SCHEMBL3713761 | 0.85 | PDK2 (0.46) | HTTL3MBTL1CNR1EPHX2SMO | |
| SCHEMBL309655 | 0.81 | F13A1 (0.48) | EPHX2HCRTR1HCRTR2MAPT | |
| SCHEMBL12965416 | 0.81 | F13A1 (0.48) | EPHX2HCRTR1HCRTR2MAPT | |
| SCHEMBL752288 | 0.78 | TSHR (0.60) | HTTL3MBTL1GAALMNASMO | |
| SCHEMBL3713949 | 0.76 | ATM (0.50) | L3MBTL1CNR1SMO | |
| SCHEMBL5321245 | 0.74 | HTT (0.51) | HTTL3MBTL1SMO | |
| SCHEMBL5653994 | 0.74 | HTT (0.51) | HTTL3MBTL1SMO | |
| SCHEMBL3713826 | 0.74 | SMO (0.52) | L3MBTL1CNR1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | claimed |
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |