SCHEMBL3715567

SCHEMBL3715567

COc1cccc(OC)c1C(=O)N1CC[C@@H](Nc2cnc3cc(Cl)ccc3n2)C1.COc1cccc(OC)c1C(=O)N1CC[C@@H](Nc2cnc3ccccc3n2)C1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 8/20 0.52
HCRTR2 O43614 7/20 0.52
CCNA2 P20248 6/20 0.43
CDK2 P24941 6/20 0.43
CDK7 P50613 6/20 0.43
CCNH P51946 6/20 0.43
MNAT1 P51948 6/20 0.43
CCNK O75909 5/20 0.43
CDK12 Q9NYV4 5/20 0.43
PDGFRB P09619 3/20 0.43
PDGFRA P16234 3/20 0.43
JAK3 P52333 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4243140 0.97 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL4243127 0.97 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL4249808 0.96 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL4249801 0.96 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL4244142 0.92 HCRTR2 (0.60) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL3654286 0.92 HCRTR2 (0.60) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL4239319 0.88 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL3656702 0.88 HCRTR1 (0.48) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL3659905 0.87 KDM4E (0.51) HCRTR1HCRTR2CCNA2CDK2CDK7
SCHEMBL8226172 0.85 PDGFRB (0.48) HCRTR1HCRTR2PDGFRBPDGFRAJAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2234999-A1 HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2010-10-06 EP claimed
WO-2009080533-A1 HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2009-07-02 WO claimed