Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913565 | 0.89 | JAK3 (0.53) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL913567 | 0.89 | JAK3 (0.53) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL913648 | 0.82 | JAK3 (0.50) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL915211 | 0.81 | IRAK4 (0.72) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL915210 | 0.81 | IRAK4 (0.72) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL913797 | 0.80 | JAK3 (0.49) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL3712540 | 0.80 | JAK3 (0.48) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL914146 | 0.79 | JAK3 (0.69) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL12904687 | 0.78 | IRAK4 (0.48) | JAK3IRAK4TYK2JAK2JAK1 | |
| SCHEMBL914045 | 0.75 | JAK3 (0.55) | JAK3IRAK4TYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |