Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.39 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335478 | 0.97 | LPAR1 (0.51) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3702206 | 0.94 | LPAR1 (0.47) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3708490 | 0.94 | LPAR1 (0.43) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3703092 | 0.93 | LPAR1 (0.46) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3712525 | 0.91 | LPAR1 (0.57) | LPAR1LPAR3LPAR2SLC26A6ABCC3 | |
| SCHEMBL3707585 | 0.91 | LPAR1 (0.53) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3705664 | 0.90 | LPAR1 (0.47) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3704739 | 0.90 | LPAR1 (0.42) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL2341940 | 0.90 | LPAR1 (0.42) | LPAR1LPAR3LPAR2NLRP3SLC26A6 | |
| SCHEMBL3705147 | 0.89 | LPAR1 (0.43) | LPAR1LPAR3LPAR2NLRP3SLC26A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |