Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 16/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.54 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.54 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649456 | 0.87 | PRKAA2 (0.70) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL647386 | 0.80 | PRKAA2 (0.75) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16927795 | 0.79 | PRKAA2 (0.72) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL647029 | 0.76 | PRKAA2 (0.69) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL519008 | 0.75 | PRKAA2 (0.83) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16927794 | 0.75 | PRKAA2 (0.64) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL649210 | 0.75 | PRKAA2 (0.67) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10112714 | 0.75 | PRKAA2 (0.67) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4402628 | 0.75 | PRKAA2 (0.56) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL648149 | 0.75 | PRKAA2 (0.56) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |