Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 18/20 | 0.80 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.80 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.80 |
| ▸ | BRD4 | O60885 | 2/20 | 0.80 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.80 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.80 |
| ▸ | MTOR | P42345 | 2/20 | 0.80 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.58 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.58 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13049032 | 0.91 | PRKDC (0.66) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL600096 | 0.89 | PRKDC (1.00) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL29373835 | 0.89 | PRKDC (1.00) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL29380743 | 0.89 | PRKDC (1.00) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL30203800 | 0.89 | PRKDC (1.00) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL3717990 | 0.88 | PRKDC (0.80) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL3715022 | 0.87 | PRKDC (0.77) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL3717584 | 0.83 | PRKDC (0.68) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL1942262 | 0.83 | PRKDC (0.77) | PRKDCBRDTPIK3CDBRD4PIK3CA | |
| SCHEMBL3714756 | 0.82 | PRKDC (0.67) | PRKDCBRDTPIK3CDBRD4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |