Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.65 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664014 | 0.95 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL2124895 | 0.92 | S1PR1 (0.58) | S1PR1S1PR3CYP2C9 | |
| SCHEMBL2125906 | 0.90 | S1PR1 (0.67) | S1PR1S1PR3 | |
| SCHEMBL3664817 | 0.88 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL3716238 | 0.87 | S1PR1 (0.64) | S1PR1S1PR3 | |
| SCHEMBL3664011 | 0.83 | S1PR1 (0.62) | S1PR1S1PR3 | |
| SCHEMBL2123484 | 0.81 | S1PR1 (0.63) | S1PR1S1PR3CYP2C9 | |
| SCHEMBL3664816 | 0.81 | S1PR1 (0.62) | S1PR1S1PR3 | |
| SCHEMBL2125344 | 0.81 | S1PR1 (0.53) | S1PR1S1PR3 | |
| SCHEMBL10130678 | 0.79 | S1PR1 (0.77) | S1PR1S1PR3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225233-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P) | Glaxo Group Limited (GB) | 2010-09-08 | — | — | EP | disclosed |
| EP-2222671-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | Glaxo Group Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009080724-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080728-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |