SCHEMBL3716348

SCHEMBL3716348

C#CCCn1c(NCCc2ccc(C(F)(F)F)cc2)nc2c(c1=O)CN(C(=O)c1ccc(C(=O)N(C)C)cc1)CC2

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PRLHR P49683 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3716287 0.91 PRLHR (0.65) PRLHR
SCHEMBL3713280 0.91 PRLHR (0.64) PRLHR
SCHEMBL437521 0.86 PRLHR (1.00) PRLHR
SCHEMBL3714330 0.84 PRLHR (0.55) PRLHR
Hydrochloric Acid SCHEMBL3722960 0.83 PRLHR (0.73) PRLHR
SCHEMBL3716345 0.82 PRLHR (0.69) PRLHR
SCHEMBL3716514 0.81 PRLHR (0.76) PRLHR
Hydrochloric Acid SCHEMBL3723877 0.79 PRLHR (0.65) PRLHR
Hydrochloric Acid SCHEMBL3717573 0.79 PRLHR (0.75) PRLHR
SCHEMBL449834 0.78 PRLHR (1.00) PRLHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010137738-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-12-02 WO disclosed