SCHEMBL3716612

SCHEMBL3716612

O=C(NO)c1ccnc(-c2ccc(OCc3cccnc3)cc2)c1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.67
SMPD1 P17405 3/20 0.62
KDM1A O60341 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
HDAC5 Q9UQL6 1/20 0.54
RAB9A P51151 1/20 0.52
GPR132 Q9UNW8 10/20 0.52
ADAM17 P78536 1/20 0.50
CMKLR2 P46091 1/20 0.50
CMKLR1 Q99788 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3713068 0.89 HDAC1 (0.82) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3713509 0.87 MRGPRX4 (0.51) HDAC1RAB9AGPR132
SCHEMBL3718643 0.86 HDAC1 (0.69) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3713865 0.84 HDAC1 (0.78) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL13188197 0.81 HDAC1 (0.64) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3713391 0.80 HDAC6 (0.70) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL13188641 0.80 HDAC1 (0.69) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3713063 0.79 HDAC1 (0.66) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3714897 0.78 HDAC1 (0.52) HDAC1SMPD1KDM1AHDAC2HDAC8
SCHEMBL3712555 0.74 HDAC1 (0.62) HDAC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010100475-A1 HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2010-09-10 WO disclosed
WO-2010100475-A1 HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2010-09-10 WO disclosed