Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 20/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709708 | 0.93 | AVPR1B (0.53) | AVPR1BCYP3A4OXTRAVPR1A | |
| SCHEMBL1874574 | 0.90 | AVPR1B (0.68) | AVPR1BCYP3A4 | |
| SCHEMBL1871405 | 0.90 | AVPR1B (0.71) | AVPR1BCYP3A4 | |
| SCHEMBL1878697 | 0.89 | AVPR1B (0.70) | AVPR1BCYP3A4 | |
| SCHEMBL1878078 | 0.89 | AVPR1B (0.69) | AVPR1BCYP3A4 | |
| SCHEMBL1876000 | 0.86 | AVPR1B (0.63) | AVPR1BCYP3A4 | |
| SCHEMBL1875174 | 0.84 | AVPR1B (0.67) | AVPR1BCYP3A4 | |
| SCHEMBL17975565 | 0.84 | AVPR1B (0.43) | AVPR1BCYP3A4 | |
| SCHEMBL1878442 | 0.83 | AVPR1B (0.60) | AVPR1BCYP3A4 | |
| SCHEMBL3718594 | 0.83 | AVPR1B (0.43) | AVPR1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227463-B1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | ABBVIE DEUTSCHLAND (DE) | 2016-08-17 | — | — | EP | disclosed |
| EP-2227463-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | Abbott GmbH & Co. KG (DE) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009083559-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | ABBOTT GMBH & CO. KG (DE) | 2009-07-09 | — | — | WO | disclosed |