Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.59 |
| ▸ | AKT2 | P31751 | 2/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.46 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720578 | 0.90 | AKT1 (0.58) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3720574 | 0.90 | AKT1 (0.58) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3774558 | 0.80 | AKT1 (0.45) | AKT1 | |
| SCHEMBL3731039 | 0.80 | AKT1 (0.72) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3731036 | 0.80 | AKT1 (0.72) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3721951 | 0.79 | AKT1 (0.61) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3721947 | 0.79 | AKT1 (0.61) | AKT1AKT2AKT3AKT1S1 | |
| Hydrochloric Acid SCHEMBL3725200 | 0.79 | AKT1 (0.70) | AKT1AKT2AKT3AKT1S1 | |
| Hydrochloric Acid SCHEMBL3725195 | 0.79 | AKT1 (0.70) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL3741797 | 0.79 | AKT1 (0.50) | AKT1AKT2AKT3AKT1S1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |