Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazoline SCHEMBL16444698 | 0.88 | EGFR (0.77) | EGFRPIK3CAPIK3CDCHRNB2CHRNA4 | |
| Quinazoline SCHEMBL28094363 | 0.88 | EGFR (0.77) | EGFRPIK3CAPIK3CDTDO2PTK2 | |
| Quinazoline SCHEMBL3686138 | 0.88 | EGFR (0.77) | EGFRPIK3CAPIK3CDCHRNB2CHRNA4 | |
| Quinazoline SCHEMBL29144630 | 0.85 | EGFR (0.71) | EGFRPIK3CAPIK3CDCHRNB2CHRNA4 | |
| Quinazoline SCHEMBL27875528 | 0.84 | EGFR (0.77) | EGFRPIK3CAPIK3CDCHRNB2CHRNA4 | |
| Quinazoline SCHEMBL6569237 | 0.83 | EGFR (0.69) | EGFRPIK3CAPIK3CDCHRNB2CHRNA4 | |
| Quinazoline SCHEMBL27788096 | 0.82 | EGFR (0.95) | EGFRPIK3CAPIK3CDTDO2KDM4E | |
| Quinazoline SCHEMBL29356169 | 0.80 | EGFR (1.00) | EGFRPIK3CAPIK3CDTDO2KDM4E | |
| Quinazoline SCHEMBL29490398 | 0.80 | EGFR (1.00) | EGFRPIK3CAPIK3CDTDO2KDM4E | |
| Quinazoline SCHEMBL22833783 | 0.80 | EGFR (1.00) | EGFRPIK3CAPIK3CDTDO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950844-A | Crystal form of morpholinyl quinazoline compound, preparation method and application thereof | 上海璎黎药业有限公司 | 2020-04-03 | — | — | CN | claimed |
| CN-1451009-A | Glucocortiocoid-selective antinflammatory agents | ABBOTT LAB (US) | 2003-10-22 | — | — | CN | claimed |
| CN-110950844-A | Crystal form of morpholinyl quinazoline compound, preparation method and application thereof | 上海璎黎药业有限公司 | 2020-04-03 | — | — | CN | disclosed |
| WO-2020063368-A1 | CRYSTAL FORM OF MORPHOLINO QUINAZOLINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海璎黎药业有限公司 | 2020-04-02 | — | — | WO | disclosed |
| CN-101115470-B | Two-piece capsule comprising a preliminary closure for accommodating pharmaceutical preparations for powder inhalers | BOEHRINGER INGELHEIM INT | 2011-04-20 | — | — | CN | disclosed |
| WO-2010120987-A1 | RING FUSED, UREIDOARYL- AND CARBAMOYLARYL-BRIDGED MORPHOLINO-PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| CN-101505757-A | Pharmaceutical combination for the treatment of airway diseases | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101426505-A | Dihydrothienopyrimidine for treating inflammatory disorders | BOEHRINGER INGELHEIM INT (DE) | 2009-05-06 | — | — | CN | disclosed |
| CN-1688349-A | Compositions and methods for coating medical implants | ANGIOTECH PHARM INC (CH) | 2005-10-26 | — | — | CN | disclosed |
| CN-1422953-A | Gene sequence of Japanese shistosome China mainland strain gynecophoric canal protein | SHANGHAI DOMESTIC ANIMAL PARAS (CN) | 2003-06-11 | — | — | CN | disclosed |