Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082357 | 0.78 | ESR2 (0.53) | ESR2NR1H2GPR119MAPK1NPC1 | |
| SCHEMBL7082361 | 0.77 | NR1H2 (0.54) | ESR2NR1H2GPR119MAPK1MAPT | |
| SCHEMBL719713 | 0.74 | NR1H2 (0.62) | ESR2NR1H2GPR119MAPK1MAPT | |
| SCHEMBL1294417 | 0.73 | ESR2 (0.50) | ESR2NR1H2GPR119MAPK1POLB | |
| SCHEMBL5458949 | 0.72 | ESR2 (0.52) | ESR2NR1H2GPR119MAPK1MAPT | |
| SCHEMBL2313024 | 0.72 | ESR2 (0.48) | ESR2NR1H2GPR119MAPTKDM4E | |
| SCHEMBL2312041 | 0.72 | ESR2 (0.48) | ESR2NR1H2GPR119MAPTNPC1 | |
| SCHEMBL1225127 | 0.71 | USP2 (0.58) | NR1H2GPR119MAPK1MAPTKDM4E | |
| SCHEMBL587550 | 0.71 | USP2 (0.58) | NR1H2GPR119MAPK1MAPTKDM4E | |
| SCHEMBL8286 | 0.71 | USP2 (0.58) | NR1H2GPR119MAPK1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096384-A2 | FUSED BENZAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-08-26 | — | — | WO | disclosed |