Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714377 | 0.92 | PRKDC (0.66) | PRKDCPIK3CAPIK3CDPIK3CBTP53 | |
| SCHEMBL3718685 | 0.88 | PRKDC (0.71) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3718030 | 0.87 | PRKDC (0.68) | PRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3796411 | 0.87 | PRKDC (0.70) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3715572 | 0.87 | PRKDC (0.70) | PRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3715509 | 0.87 | PRKDC (0.70) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3716359 | 0.86 | PRKDC (0.79) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3717044 | 0.86 | PRKDC (0.64) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3717596 | 0.86 | PRKDC (0.68) | PRKDCPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL13049072 | 0.86 | PRKDC (0.68) | PRKDCPIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |