Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.61 |
| ▸ | QDPR | P09417 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537443 | 0.86 | HTR2C (0.57) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL4949183 | 0.86 | HTR2C (0.57) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL5584686 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL30228395 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4893701 | 0.85 | HTR2C (0.58) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL31342813 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL29623419 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL2710169 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL17102301 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL30228726 | 0.85 | HTR2C (0.56) | HTR2CQDPRHTR2ASLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398796-A1 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Canada Inc. (CA) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010094126-A1 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2010-08-26 | — | — | WO | disclosed |